3D Printing Realizes Regeneration Of Broken Bones, Uas Yuav Hloov Kho Cov Tshuaj Kho Mob

Hauv kaum xyoo tsis ntev los no, kev tshawb fawb txog kev kho mob tau ua tiav tseem ceeb, muab cov kev daws teeb meem tshiab rau cov kab mob nyuaj yav dhau los. Ib txoj kev tshawb fawb luam tawm tau pom tias ib txoj hauv kev siv 3D luam ntawv los tsim cov pob txha tuaj yeem hloov kho cov tshuaj kho dua tshiab.

Regenerative tshuaj yog ib ceg ntawm kev kho mob science uas txhim kho kev kho mob los hloov cov ntaub so ntswg, kab mob thiab cov hlwb puas los ntawm cov kab mob, tsis xws luag los yog raug mob. Qhov no yog hom tshiab ntawm kev tshawb fawb txog kev kho mob, uas xav tias yuav pab cov neeg mob uas muaj kab mob thiab raug mob uas yav tas los nyuaj kho.

Nano-structured bioactive cov ntaub ntawv tau nyiam nyob rau hauv daim teb no vim lawv muaj peev xwm regenerative. Lawv replicate cov yam ntxwv ntawm cov ntaub so ntswg thiab xyaum lawv cov qauv. Cov ntaub ntawv kho mob siab heev no tuaj yeem ua tiav thiab siv tau siv 3D luam ntawv thiab lwm yam thev naus laus zis.

Regenerating pob txha cov ntaub so ntswg: ib qho tseem ceeb kho mob ua ntej

Kev laus tuaj yeem ua rau muaj teeb meem kev noj qab haus huv. Cov kab mob xws li osteoporosis yuav tshwm sim thaum cov neeg mob hnub nyoog, ua rau mob rau tib neeg thiab ua rau lub nra hnyav ntawm kev kho mob. Kev kho ib txwm muaj xws li pob txha grafts. Tsis tas li ntawd, lwm txoj hauv kev tsis tuaj yeem ua raws li cov yam ntxwv thiab cov qauv ntawm cov ntaub so ntswg. Vim li no, ntau qhov kev tshawb fawb tshiab suav nrog cov pob txha pob txha engineering tau tsim.

Kev ua haujlwm ntawm cov pob txha cov ntaub so ntswg koom nrog kev tsim cov khoom siv biomimetic uas txhawb cov pob txha loj hlob thiab txhawb kev tsim dua tshiab. Advanced bioactive cov ntaub ntawv yog 3D luam tawm rau hauv kev ua haujlwm scaffolds rau siv hauv pob txha cov ntaub so ntswg engineering technology.

Cov no cuam tshuam nrog lub hom phiaj cov ntaub so ntswg thiab induce kho cov lus teb. Cov khoom sib xyaw ua ke yog raws li hom 1 collagen thiab hydroxyapatite (tseem siv hauv kev kho hniav) vim tias lawv yog cov khoom tseem ceeb ntawm cov pob txha.

Cov khoom siv biomimetic sib xyaw ua rau cov lus teb osteopathic, uas ua rau kev loj hlob, kev loj hlob, thiab kev sib txawv. Qhov no ua rau cov pob txha rov tsim dua tshiab. Feem ntau siv 3D luam ntawv thev naus laus zis hauv kev tsim khoom hauv kev tsim cov pob txha pob txha yog extrusion molding. Qhov no yog vim nws versatility thiab scalability. Txawm li cas los xij, tseem muaj ntau qhov teeb meem tseem ceeb hauv kev tsim cov khoom siv hluav taws xob muaj zog thiab ruaj khov rau cov pob txha rov siv dua.

Kev hloov pauv hauv viscosity (A) thiab viscoelastic zog ntawm GEN-Coll / nanoHA (B) thiab GEN-Coll / MBG_Sr4% (C) ntawm 10 ° C

Hom 1 bovine collagen yog cov khoom cog lus rau kev tsim cov pob txha puas lossis kab mob. Cov ntaub ntawv bioactive no muaj cov khoom siv nplua nuj nanoparticles thiab tuaj yeem yooj yim 3D luam tawm siv lub da dej txhawb nqa. Txawm li cas los xij, muaj qee qhov teeb meem nrog lawv siv. Lawv nyuaj rau tshem tawm tag nrho tom qab cov txheej txheem luam ntawv, thiab tus neeg sawv cev sib txuas siv los txhim kho cov qauv kev ncaj ncees ntawm cov stent yuav ua rau poob ntawm geometric clarity thiab ib feem ntawm cov ntawv luam tawm.

Lwm cov txheej txheem yuav tsum tau kov yeej cov kev txwv ntawm cov khoom siv biomaterials.

Tam sim no, pab pawg tshawb fawb tau npaj ib txoj hauv kev los ua kom muaj zog thiab tsim nyog cov khoom siv bioactive raws li bovine collagen, uas yuav pab txhawb kev hloov pauv cov thev naus laus zis ntawm tib neeg cov pob txha rov tsim dua tshiab.

Cov txheej txheem qhia nyob rau hauv daim ntawv lub hom phiaj los txhim kho cov khoom ntawm bovine collagen tsim. Tus neeg sawv cev crosslinking tau ntxiv rau cov qauv luam ntawv, thiab tom qab ntawd lawv raug tshem tawm los ntawm kev txhawb nqa da dej. Tus neeg sawv cev sib txuas ntawm kev xaiv yog genipin, uas txhim kho kev ruaj ntseg ntawm collagen 3D luam ntawv scaffold qauv los ntawm kev ua rau hauv-situ cross-linking.

Cov tshuaj siv rau kev txhawb nqa da dej yog alginic acid. Cov kev tshawb fawb tau pom tias alginic acid tswj cov qauv 3D luam tawm ntawm cov khoom siv collagen thiab tau yooj yim tshem tawm ntawm 37 o C, uas tso cai rau kev ua haujlwm ruaj khov ntawm cov qauv nrog cov qauv geometric siab. Cov txheej txheem tau tsim los siv cov txheej txheem tsim ua ntej.

Tom qab incubating rau 3 teev thiab 24 teev ntawm 37 ° C, ua amplitude scan test (A, C) thiab kub ramp (B, D) ntawm GEN-Col / nanoHA

Xaiv honeycomb thiab daim phiaj geometry los ntsuas qhov luam tawm ntawm cov khoom. Ntau qhov kev sim tau ua nrog qhov sib txawv los muab kev tswj hwm qib zoo thiab muab kev nkag siab txog cov txiaj ntsig. Kev cuam tshuam ntawm txhua qhov kev ntsuas ntawm kev ncaj ncees ntawm kev luam ntawv thiab kev daws teeb meem ntawm cov qauv scaffold zaum kawg yog lub hauv paus ntawm kev hloov pauv.

Txoj kev tshawb no xaus lus tias cov kev ntsuas no yuav tsum tau kho kom zoo kom ua tiav cov txiaj ntsig xav tau vim tias lawv muaj kev cuam tshuam.

Kev tsom xam pom ntawm lub tshuab luam ntawv tau lees paub tias cov txheej txheem luam ntawv tau ua tiav tiav geometric luam tawm. Cov kab ntshiab thiab qhov yog tsim. Tom qab lyophilization, morphology tau soj ntsuam los ntawm FE-SEM, uas qhia tau hais tias cov nanoparticles tau ntse faib rau hauv matrix.

Cov txiaj ntsig no qhia tau hais tias kev siv cov txheej txheem no rau 3D luam ntawv ntawm cov ntaub ntawv collagen qhia tau hais tias muaj txiaj ntsig zoo hauv kev tsim cov pob txha.